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Objective To investigate the application value of procalcitonin(PCT) in fever of the patients with malignant tumor.Methods A total of 254 patients with malignant tumor complicating fever from January to October 2016 were collected and grouped after clearly diagnosing the causes of body temperature increase according to the clinical manifestations,laboratory examination and imaging examination results.The difference of PCT level was compared among various groups.Results Compared with tumor thermal group,the PCT level in the sepsis and non-sepsis groups was significantly increased(P<0.001).Moreover no matter which was bacterial infection,fungal infection or both mixed infection,the PCT level was significantly higher than that in the tumor thermal group;compared with the fungal infection group,the PCT level in the bacterial infection group was increased significantly(P<0.01).The PCT level distribution difference among the tumor thermal group,fungal infection group and bacterial infection group was statistically significant(P<0.01).The critical values of PCT for diagnosing fungal and bacterial infectious fever were 0.575,0.945 ng/mL respectively.The areas under ROC curve were 0.812(95%CI:0.805-0.934);0.951(95%CI:0.917-0.985).Conclusion It is priliminarily considered that PCT can serve as an effective clinical auxiliary diagnostic indicator for differentiating the fever cause in the patients with malignant tumor.
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Objective To explore the effects of human papilloma(HPV) infection status on the DNA ploidy of cervical epi-thelial cells in Uygur and Han women .Methods Totally 348 women collected who initially received treatment in Tumor Hospital Affiliated to Xinjiang Medical University from July 2012 to June 2014 ,including 181 cases of Uygur and 167 cases of Han women . HPV genotyping was dased on cytology specimens from thin layer of liquid ,and DNA ploidy analyze [DNA index(DI) and S phase cells ratio(SPF)] was conducted by using flow cytometry .All the patients were divided into negative infection group ,non high-risk infection group ,single high-risk HPV infection group and mixed high-risk HPV infection group according to HPV gene type .Re-sults There were statistically significance between Uygur and Han women of DI and SPF in the single high-risk HPV infection group(P= 0 .033 ,P< 0 .01) ,it also present the same trend in mixed high-risk HPV infection group(P = 0 .031 ,P< 0 .01) .It was 19 .783 times and 59 .231 times to appear DNA aneuploid in single high-risk HPV infection and mixed high-risk HPV infection compared to the HPV negative infection group in Uygur women .It was 11 .190 times and 22 .125 times in Han women . Conclusion Single high-risk type HPV infection and mixed high-risk HPV infection had different impact on cervical lesions be-tween Han and Uygur women .It was necessary to respectively study the correlation between cervical lesions and HPV infection for each ethnic groups .
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Objective To investigate the concentration of Golgi glycoprotein 73(GP73) in ascites, then study the value of GP73 and alpha fetal protein(AFP)in the differential diagnosis of ascites.Methods Totally 96 malignant ascites specimens , 35 benign ascites specimens and their paired serum specimens were collected in the Tumor Hospital Affiliated to Xinjiang Medical University from November 2012 to November 2013.GP73 in serum and ascites were detected by ELISA and AFP in ascites was measured by electrochemical luminescence.The application values of GP 73 and AFP were evaluated through ROC curve.Results In benign ascites group , the difference of GP73 between the ascites ( 16.06 ±9.53 ) ng/ml and the serum (13.69 ±8.87) ng/ml was statistically significant (t=5.026,P<0.001), which showed a good linear correlation (r=0.966,P<0.001).In malignant ascites group, the difference between the ascites (28.37 ±12.02) ng/ml and the serum (16.06 ±9.53) ng/ml was statistically significant (t=10.641,P<0.001), and also showed a good linear correlation (r=0.933,P<0.001).The cutoff values of GP73, AFP and GP73*AFP (GP73 multiplied AFP) for diagnosing the malignant ascites were 17.1 ng/ml, 13.1 ng/ml and 321.The area under ROC curve ( AUC) were 0.795, 0.753 and 0.902 respectively.The AUC of GP73*AFP is the largest.The sensitivity of three index diagnosing the ascites , were 89.6%( 86/96 ) , 88.5%(85/96) and 86.4%(83/96); and the specificity were 60.0%(21/35), 54.2%(19/35) and 85.7%( 30/35 ) respectively.Conclusions Detection of GP73 in ascites specimens has clinical value , GP73*AFP was the best indicators for differential diagnosis of benign and malignant ascites compared to GP73 and AFP.